About Vision at Johnson & Johnson

Johnson & Johnson has a deep legacy in developing transformational new products that improve the health of patients’ eyes. As a global leader in eye-health, we have a bold ambition: Vision Made Possible – and are paving the way for a new future of eye health to support the full spectrum of pediatric, developed and mature eyes. Through cutting-edge innovation, scientific expertise, and advanced technologies, we are revolutionizing the way people see and experience the world. At every step of the eye health journey – from investigational gene therapies for retinal diseases to contact lenses and refractive and cataract surgical solutions – we stand as a trusted partner with the goal of making vision possible for customers and patients. Visit us at jjvision.com, follow @JNJVision on Twitter, Johnson & Johnson Vision on LinkedIn, and @JNJVision on Facebook.

About CooperVision

CooperVision, a division of CooperCompanies (Nasdaq:COO), is one of the world’s leading manufacturers of contact lenses. The company produces a full array of daily disposable, two-week and monthly soft contact lenses that feature advanced materials and optics, and premium rigid gas permeable lenses for orthokeratology and scleral designs. CooperVision has a strong heritage of addressing the toughest vision challenges such as astigmatism, presbyopia, childhood myopia, and highly irregular corneas; and offers the most complete portfolio of spherical, toric and multifocal products available. Through a combination of innovative products and focused practitioner support, the company brings a refreshing perspective to the marketplace, creating real advantages for customers and wearers. For more information, visit www.coopervision.com

Bravo Vision Optical Limited (Distributor of SEED in Hong Kong & Macau)

With a legacy dating back to 1951, SEED embarked on pioneering research in contact lenses. Over the ensuing half-century, we harnessed cutting-edge technologies and fostered unwavering customer trust through our contact lens innovations. Our expertise extends beyond lenses, as we’ve introduced a diverse range of eye-related products to the market. Guided by our corporate philosophy of “Supporting Your Vision with Japanese Quality,” we operate across diversified business domains. As we continue to nurture vision, we remain steadfast in planting "SEED"s in new frontiers, reaping the fruits of our unwavering efforts. Since 2013, Bravo Vision Optical Limited has proudly served as the distributor of SEED in Hong Kong and Macau.

For more information, please visit: https://bv-optical.com/

At Loyal Tech Group, we are constantly striving to improve and expand our product range to meet the evolving needs of our customers. Our aim is to become a trusted partner for ophthalmic professionals by providing top-notch products and unparalleled service.

For more information, please visit: http://www.loyaltech.com.hk/

Headquartered in Singapore, Oculus Private Limited and its group of subsidiaries have over 30 years of experience in manufacturing and supplying high quality contact lens and contact lens care products to eye care practitioners and optical retailers.

Oculus is focused on the innovation, manufacturing and marketing of cosmetic contact lenses and has established FreshKon® as a leading brand of cosmetic contact lens in South East Asia and China. The Oculus group also offers disposable clear contact lenses under FreshKon® brand, specialty contact lens products such as gas permeable lenses under OCUVIQ brand and soft toric contact lenses under Flexcon brand. Oculus’s products are manufactured in accordance to the quality assurance system ISO 13485 requirements and meet the Medical Devices Directive 93/42/EEC.

Oculus has a direct presence in Singapore, China, Hong Kong, Malaysia, Indonesia, and Taiwan, with a network of international distribution partners, Oculus’s products are sold in over 50 countries globally.

Alcon is the global leader in eye care, dedicated to helping people see brilliantly. With an over 75-year heritage, we are the largest eye care device company in the world, with complementary businesses in Surgical and Vision Care. Being a truly global company, we work in over 50 countries and serve patients in more than 140 countries. We have a long history of industry firsts, and each year we commit a substantial amount in Research and Development to meet customer needs and patient demands.

To learn more about Alcon: Alcon Eye Care for Healthcare Professionals | MyAlcon

About Euclid Vision Corporation

Euclid Vision Corporation is a world leader in myopia management and manufacturer of advanced orthokeratology lens products. With headquarters in Virginia, USA, and offices in Shanghai and Beijing, China, Euclid is leading the efforts in myopia management across the globe.

Multiple clinical studies worldwide by prestigious independent researchers have proven the effectiveness of orthokeratology, and specifically the Euclid Emerald lens, on slowing the progression of myopia. The Euclid Emerald lens design has received FDA approval in the U.S., South Korea, Japan, Taiwan, China and CE mark for Europe. Nearly three million successfully treated Ortho-K patients in the modern Euclid Emerald family of lenses, has proven them to be easy to fit while providing highly effective myopia reduction.

At Euclid, our mission is to improve the lives of patients globally by providing the best technology and highest quality solutions for myopia management. On the front lines of the Myopia Epidemic since 1995, Euclid is making a difference around the world by supporting the development of optometry, eye health promotion and myopia management in children worldwide.

About Skyview

Since launched in 1987, Skyview had become accepted as a principal supplier to the optical and ophthalmic profession.

Our reputation is built upon the reliable supply of an extensive range of high quality instruments and machines in conjunction with world class partners.

OUR VISION
To be the best optical instrument provider thus assisting to enhance the service quality of the Ophthalmologist and Optometrist in the area we served by bringing in New and Advance technology and latest innovated Ophthalmic and Optical devices resulting in offer with better choice of treatment and service to the people.

OUR MISSION
We strive to act with honesty, openness, fairness and integrity to help to enhance the service quality and support of the Optical and Ophthalmic field in the area we served. We provide opportunities for the growth and enrichment to our employees, our business partners and the communities in which we operate.

Objective: To investigate the clinical efficacy and safety of transcutaneous electrical acupoint stimulation（TEAS）in the treatment of dry eye.

Methods: 60 patients meeting the diagnostic criteria of dry eye were randomly divided into test group (30 cases) and control group (30 cases). The experimental group was treated with transcutaneous electrical acupoint stimulation（TEAS）, the current was applied to the acupoints around the eyes (temples and foot Shaoyang gallbladder meridian), and the experimental group was treated with traditional acupuncture therapy. The treatment period was 2 weeks, 2 times a week. Symptom improvement, ocular surface disease index (OSDI), tear secretion, BUT and other indicators were recorded during the period.

Results: After treatment, dry eye symptoms were significantly improved in most patients. Dry eyes, foreign body sensation, burning sensation and other discomfort symptoms reduced or disappeared; Ocular surface disease index (OSDI) changes; Increased tear secretion; BUT was increased (P<0.05).

Conclusion: transcutaneous electrical acupoint stimulation（TEAS）is effective and safe in the treatment of dry eye. The treatment effectively improves the symptoms of dry eye patients by promoting blood circulation in the eye, increasing tear secretion, prolonging BUT, relieving ocular muscle tension, regulating nerve conduction function and other mechanisms.

Tears play a crucial role in maintaining the health and function of the ocular surface as they cover the surface of the eye. Their composition is complex. Compared to other bodily fluids, tears are easier to collect, non-invasive, and painless. These characteristics make tears an ideal source of biomarkers for diagnosing and monitoring various diseases, especially systemic metabolic disorders such as diabetes and its complications.

Diabetes is a metabolic disease, and there is currently no fundamental cure. Early diagnosis and monitoring of diabetes is crucial for patient treatment and prognosis. In recent years, biomarkers in tear fluid have garnered significant attention from researchers due to their unique advantages. Studies have shown that various metabolites are upregulated in the tear fluid of diabetic patients, related to the pathogenesis of diabetes. For example, niacin levels are elevated in the tears of diabetic patients. Additionally, the levels of the pro-inflammatory cytokine TNF-α in the tear fluid of patients with diabetic retinopathy (DR) are increased, which not only aids in the early diagnosis of DR but also helps predict the severity of the disease. The correlation between tear fluid levels of Nerve Growth Factor (NGF) and diabetic nephropathy, Neuropeptide Y (NPY) and diabetic peripheral microangiopathy, and MMP-9 and diabetic peripheral neuropathy (DPN) suggests the potential value of tear fluid biomarkers for the prediction and diagnosis of diabetic complications.

Despite the potential of tear biomarkers in the diagnosis and monitoring of diabetes and its complications, their clinical application still faces challenges. For instance, tear samples are often small and technically demanding to collect and detect, limiting their widespread use. However, with the advancement of analytical techniques, in the future, tear analysis is expected to become a routine tool for detecting the diagnosis and monitoring of diabetes and its complications, and to play a more important role in the management of diabetes.

Purpose: Emerging evidence has indicated that specially designed daily disposable soft contact lenses (SCL) can slow down myopia progression. This study investigated the long-term impact of hydrogel SCL on corneal endothelium and corneal morphological characteristics in children.

Method: Twenty participants (mean age: 20.6 ± 1.5 years) who wore daily disposable SCL (omafilcon A) for myopia correction or treatment from ages 8-12 years and twenty age-matched controls without contact lens experience were recruited. The central corneal endothelium was photographed from each eye with a non-contact specular biomicroscope. A minimum of 100 contiguous cells, marked manually on each image using the centre-dot method, was analysed with built-in computer algorithms. Average values of endothelial cell density (ECD), average cell area (ACA), coefficient of variation of cell area (CV), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were obtained from three images of each eye.

Results: Intra-class correlation indicated a strong correlation between the two eyes (ICC ≥ 0.9). Data from both eyes were averaged and analysed using an independent t-test. No significant difference was found between the two groups in average ECD (control vs SCL: 3125 ± 197 vs 3092 ± 227 cells/mm2, p>0.05), ACA (320 ± 22 vs 325 ± 25 µm2, p>0.05), HEX (68 ± 5 vs 66 ± 7 %) and CCT (555 ± 22 vs 552 ± 28 µm, p>0.05). Although 7 out of 20 SCL participants had an average CV value higher than 30, no statistically significant difference was found between the two groups (p=0.08).

Conclusions: Our study showed wearing daily disposable hydrogel SCL full-time over 10 years caused no significant long-term impact on central corneal endothelium in children who wore SCLs from 8 years of age, who had good contact lens habits and regular contact lens aftercare.

Purpose: Evaporative water loss from the front surface of a contact lens during periods of tear film break up may be a significant mode of ocular dehydration. Measurement of 22 types of CL shows that the rate of evaporation is material dependent. This work specifically addresses pervaporation which refers to water loss by the combined processes of permeation and evaporation. The experimentally measured rates are used in conjunction with a model to calculate the fraction of incoming tears lost to pervaporation.

Methods: Evaporation rates (µL/min/cm2, n=6 per material) were experimentally determined using a custom pervaporation cell with a dynamic vapor sorption instrument. Rates were measured at 35ºC and under conditions of 80%, 50%, 30% and 0% relative humidity (RH). The experimentally measured evaporation rates, along with values for the area of exposed lens polymer and exposure time between blinks, were used to create a model for evaporative loss from the lens polymer during periods of tear film break up.

Results: The lenses fall into two groups: materials with higher pervaporation rates that are strongly dependent on percent RH, and materials with lower rates that resist pervaporative loss at low humidity. Group with higher rates contains both traditional and silicone hydrogel lenses, while the group with lower rates is composed of exclusively SiHy that contain strong hydrophilic components. Modeling shows that for high pervaporation rate lenses, up to 30% or more of the incoming tears may be lost by evaporation directly from the lens surface. Water loss is significantly reduced with lower evaporation rate lenses.

Conclusions: Evaporation of water from the surface of CL is shown to be material dependent. Pervaporative loss that occurs during periods of tear film break up may be an important mode of ocular dehydration leading to CLIDE. CL materials with strong hydrophilic components reduce pervaporative loss.

Background: Myopia is an increasingly serious threat to the visual health of young people around the world, and the orthokeratology (OK) lens are widely accepted as one of the most effective means of controlling myopia, providing a safe and reversible solution to correct and slow the progression of myopia by wearing them at night. However, the fitting process is cumbersome and the effect varies between different doctors.The application of Artificial Intelligence (AI), especially Machine Learning (ML) and Deep Learning (DL), has brought innovative breakthroughs in this field. By analysing images and data information and recognising subtle patterns, they can make more accurate and faster judgments than optometrists.

Methods: We performed a comprehensive search of PubMed, Web of Science, Embase and Scopus using the keywords 'AI, artificial intelligence, machine learning, deep learning, natural language processing, computer vision, generative AI' combined with 'orthokeratology'. A total of 147 articles were found and 21 articles were included after full-text analysis.

Results: ML and DL built prediction models based on corneal topographic map, axial length (AL), spherical equivalent refractive error (SER) and other biological characteristics to achieve the accuracy and personalization of OK lens matching, and provide a more effective myopia prevention and treatment scheme for the clinic.

Discussion: We retrospectively analyzed the current status and potential transformative impact of the application of ML and DL in AI in the control of myopia with OK lenses. The application of ML and DL in the clinical practice of controlling myopia with OK lenses has improved the accuracy and efficiency of fitting, and has shown great potential in assisting optometrists to determine trial lenses, predict correction effects, and achieve personalized treatment. We emphasized its potential to improve market shortages, and also explored in depth the challenges of integrating it into clinical practice and research.

Objectives: To investigate the rate of axial elongation (AE) and associated factors in highly myopic children treated with dual reverse curve (RC) orthokeratology (ortho-k) lenses.

Methods: Chinese children aged 7 to 13 years, with myopia ≤ -5.00 D and astigmatism ≥ -2.00 D, were assigned to either a dual RC design targeted for full correction (study) or a conventional design with -4.00 D target (control). Both groups wore single-vision spectacles to correct residual refraction during the daytime. Generalized estimated equation (GEE) model analyses were used to examine the changes in AL and ChT over time and between groups, accounting for inter-eye correlations. Some participants discontinued lens wear for over one month due to microcysts, which was considered discontinuation effect. Another GEE model analysis using the data from all the visits was used to examine the risk factors for AE, adjusting for age, sex, treatment group, inter-eye correction, baseline AL and ChT, ChT changes, and discontinuation effect.

Results: Thirty participants completed the two-year follow-up (control: 20 vs study: 10). After two years, AE was comparable between groups (0.12 ± 0.05 vs 0.14 ± 0.07 mm). Thirteen participants who discontinued temporarily for over one month during the study period demonstrated greater AE than those who did not (0.19 vs 0.08 mm). At the end of the study, there was no significant difference in the mean ChT change between groups (10.4 ± 5.1 vs 15.8 ± 5.4 µm). GEE analysis indicated that older age, greater increases in ChT, and continuous treatment were significantly associated with less AE.

Conclusion: The dual RC ortho-k design targeted for greater refractive corrections achieved good myopia control efficacy in highly myopic children, comparable to the conventional design. Younger age, less increase in ChT, and temporary lens wear discontinuation (interruption) over one month during treatment may accelerate myopia progression.

Objective: Low-Level Red Light therapy has emerged as a potential non-invasive option for managing dry eye disease, yet its underlying mechanisms remain unclear. Thus, this study aims to investigate the impact of red light on the functionalities of human corneal epithelial cells (hCECs).

Methods: An immortalized human corneal epithelial cell line was used in this study. Cells were cultured in either normal osmolar media (315 mOsm/L) or hyperosmolar media (465 mOsm/L) and exposed to LED red light (RL, 620 nm with 2500 lux or 0.88 mW, 5 times at 5-minute intervals over 24 hours). There were 4 groups, cells in normal osmolar media (C-N), cells in hyperosmolar media (C-HS), cells exposed to LED light in normal osmolar media (RL-N), and cells exposed to LED light in hyperosmolar media (RL-HS). Cell viability (annexin V and propidium iodide), intracellular ROS production (DCFH-DA), mitochondrial ROS generation (MitoSox), and their inflammatory state (anti-HLA-DR antibody) were assessed through flow cytometry.

Results: The expressions of annexin V and propidium iodide on hCECs decreased significantly sorely in the RL-N compared to the C-N group (p < 0.022). Additionally, intracellular ROS levels increased significantly in the RL-N compared to the C-N group (p = 0.023). Mitochondrial ROS generation was significantly increased in RL-C and RL-HS groups compared to their controls (p < 0.027). HLA-DR expression decreased significantly in RL-HS compared to RL-N (p = 0.027), suggesting an anti-inflammatory effect of red light.

Conclusions: Low-Level Red Light may prevent cell death and enhance ROS production in hCECs under non-stressful conditions, potentially augmenting cellular functions. Exposure to RL may have a greater impact on mitochondrial activities given the significant increase in mitochondrial ROS generation in both RL-N and RL-HS groups. Further studies are needed to better understand intracellular pathways or underlying mechanisms of RL on hCECs.

Purpose: Antibiotics have been the conventional treatment for bacterial keratitis and their use has led to significant issues including antimicrobial resistance and allergic reactions. These problems have prompted the search for alternative therapies. We developed a biocidal corneal bandage that is free of antibiotics, utilizing photo-sensitive nanocomposites embedded in an enzyme-modified hydrogel. The nanocomposites and enzymes generate reactive oxygen species (ROS) to effectively disinfect bacteria. The nanocomposites release ROS when exposed to near-infrared light (NIR), and the enzymes within the hydrogel catalyze glucose present in tear fluid to produce additional ROS.

Methods: The treatment efficacy of this antibacterial bandage was evaluated through Multi-drug resistant Pseudomonas aeruginosa (MDR-PA) induced in vivo rabbit bacterial keratitis model. The colonies of bacteria were isolated from cornea of the rabbit (N=4) after treatment. The transparency of the cornea and defects of the corneal epithelial layer was also examined with slit lamp. Besides, studies on assessing the biosafety of the bandage the histology of cornea were conducted via H&E staining and Masson staining.

Results: The living colonies of the bacteria amount in cornea from rabbit model exhibited a significant reduce to (6+/-1%) (MDR-PA) after treated with the bandage. Cornea treated with the bandage exhibited more transparency and less edema compared to the infected cornea. Bandage treated cornea indicated a faster re-epithelialization compared to infected cornea. Besides, the histological staining indicated that no damage to corneal tissue was caused by treatment with the bandage.

Conclusions: The result of reduced bacterial colonies indicated that the treatment with the bandage has potential in eliminating drug-resistant bacteria on an infected cornea. Besides, the maintenance of the corneal transparency and promoted healing of corneal epithelial layer suggested that biosafety of the bandage. The in vivo results suggested that our bandage has the potential to be a treatment alternative for bacterial keratitis.

Objective: Optometry students and ECPs often face challenges in CL learning. Firstly, accessing updated contact lens information, particularly in the Hong Kong market, where data is scarce and scattered. Traditional methods like random searches or product handbooks are inefficient. Secondly, the conventional peer-dependent rigid lens learning model lacks flexibility and limits students\' learning experiences. To address these issues, we developed an integrated contact lens learning platform to provide a comprehensive and interactive resource for contact lens education.

Methods and Results:

The developed platform features:

• Search Engine: Updated information on over 350 contact lenses and ophthalmic solutions, tailored for the Hong Kong market.
• Interactive Case Studies: Three healthy eyes with varying degrees of WTR corneal astigmatism (1.06D, 3.20D, and 6.33D) were fitted with RGP lenses of different designs and parameters. If spherical lenses failed to achieve an optimal fit, bi-toric lenses were used. These fittings were documented through videos and photographs, graded, and commented on by five experienced RGP practitioners. Data was integrated into the platform.
• Additional Learning Resources: Clinical procedure videos and self-study questions.

To evaluate the platform\'s efficacy in CL teaching, two quizzes on lens-fitting grading using recorded videos were administered to students following didactic teaching, with and without platform use. Student feedback was collected via questionnaires. Among the 26 students who participated, 65.4% improved their lens-fitting grading accuracy with platform use, showing a mean accuracy increase of 19.8±26.5% (P<0.05). Most students preferred the platform over conventional teaching alone, and all found it valuable to their learning.

Conclusion: The platform enables students and ECPs to access updated contact lens product information and provides various learning tools, including rigid contact lens case series allowing for interactive learning. This enhances their educational experience and equips them with the latest product knowledge, ultimately benefiting their future practice as optometrists.

Purpose: The safety and performance of a soft contact lens with RingBoost™ technology (RB) in Chinese children completed 6 months lens wear are being evaluated in a real-world clinical setting (Aier Eye Hospital).

Method: This is a single-site, prospective, single-arm, open-label, real-world evidence study with a minimum of 1-year study duration. Eligible participants were followed post lens fit at 1-week, 1-month, 3-month and 6-month prior to completing the 12-month follow-up for evaluation of potential adverse events, vision performance, lens fit, and lens wear compliance. Further, myopia progression is evaluated at every 6 months via measuring changes in cycloplegic autorefraction and axial length (AL).

Results: A total of 70 subjects aged 7-12 years with a mean baseline myopia of -2.21 D (SD: 0.97) were fitted with the RB lens, and 67 participants completed the 6-month follow-up. No serious or significant adverse events were reported to date. After 6 months of wearing the RB lens, mean (SD) changes from baseline in AL and spherical equivalent cycloplegic autorefraction were 0.03 (0.12) mm and -0.09 (0.30) D, respectively. Monocular distance visual acuity with the RB lens was 0.00 (0.05) and -0.03 (0.05) logMAR at initial lens fitting and 6-month follow-up, respectively. Binocular distance visual acuity at 6-month follow-up was 0.00 logMAR or better in all subjects and all eyes achieved acceptable lens fit. The mean (SD) lens wear time reported at the 6-month follow-up was 12.8 (2.0) hours per day and 6.5 (0.7) days per week. Of the 67 subjects who completed the 6-month follow-up, 98.5% had cumulative lens wear time meeting or exceeding the criterion for compliance.

Conclusion: The 6-month outcomes demonstrated excellent safety, vision and fit performance of the RB lens. Minimal AL and myopia progression were observed.